{"id":17137,"date":"2019-05-21T12:46:51","date_gmt":"2019-05-21T16:46:51","guid":{"rendered":"https:\/\/caloriecontrol.org\/childhood-fructoholism-and-fructoholic-liver-disease\/"},"modified":"2020-11-06T00:13:21","modified_gmt":"2020-11-06T05:13:21","slug":"childhood-fructoholism-and-fructoholic-liver-disease","status":"publish","type":"post","link":"https:\/\/caloriecontrol.org\/childhood-fructoholism-and-fructoholic-liver-disease\/","title":{"rendered":"Childhood Fructoholism and Fructoholic Liver Disease"},"content":{"rendered":"<p><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6312651\/pdf\/HEP4-3-44.pdf\">Download<br \/>\nPDF<\/a><\/p>\n<p>Ribeiro A, Igual-Perez MJ, Santos Silva E and<br \/>\nSokal EM.<\/p>\n<p><em>Hepatology Communication<\/em> 2019, 3:1;<br \/>\ndoi: 0.1002\/hep4.1291<\/p>\n<p><strong>Objective<\/strong><\/p>\n<ul>\n<li>To<br \/>\n     conduct a review to provide evidence of the negative effect of high<br \/>\n     fructose consumption in childhood on future liver health, with many<br \/>\n     similarities to alcohol, and to propose strategies for its reduction and to<br \/>\n     support global health improvement in the pediatric age.<\/li>\n<\/ul>\n<p><strong>Background<\/strong><\/p>\n<ul>\n<li>Nonalcoholic fatty liver disease (NAFLD) is an<br \/>\n     emerging entity, becoming the most prevalent pediatric chronic liver disease.<\/li>\n<li>Excessive fructose consumption is believed to<br \/>\n     cause addiction like alcohol and other drugs. As such, the new term<br \/>\n     &ldquo;fructoholism&rdquo; refers to the consumption of a substance (fructose) that<br \/>\n     can cause psychological and physical damage and become a major public<br \/>\n     health concern, highlighting the seriousness of the excessive consumption<br \/>\n     of fructose in the pediatric age.<\/li>\n<li>Hepatic fructose metabolization leads to<br \/>\n     hepatic steatosis and progression to fibrosis through mechanisms<br \/>\n     comparable to alcoholic liver disease, hence the term &ldquo;fructoholic liver<br \/>\n     disease.&rdquo;<\/li>\n<\/ul>\n<p><strong>Methods<\/strong><\/p>\n<ul>\n<li>No information on the methods used for this<br \/>\n     review are provided.<\/li>\n<\/ul>\n<p><strong>Findings<\/strong><\/p>\n<ul>\n<li>Recent<br \/>\n     data provide evidence of the heterogeneity of NAFLD progression in the<br \/>\n     pediatric age.&nbsp; The whole spectrum<br \/>\n     of NAFLD can be seen in childhood, from liver steatosis to cirrhosis, to<br \/>\n     liver failure and HCC. Although rare, rapid progression to cirrhosis and<br \/>\n     end-stage liver disease can disclose within a few years, and cirrhosis at<br \/>\n     diagnosis has also been described in childhood.<\/li>\n<li>Fructose<br \/>\n     intake has a dose-dependent correlation with NAFLD development and its<br \/>\n     progression to fibrosis in children and adolescents.&nbsp; This leads to a pattern of liver injury<br \/>\n     comparable to alcohol ingestion.<\/li>\n<li>Sugar<br \/>\n     addiction from the viewpoint of behavior and brain neurochemistry has been<br \/>\n     shown in animal models, in which feeding comportment during intermittent access<br \/>\n     to sugar solutions was studied, demonstrating similar addiction-related<br \/>\n     behaviors caused by drugs of abuse, including bingeing, withdrawal<br \/>\n     syndrome, cravings, and cross-sensitization.<\/li>\n<li>In<br \/>\n     addition to their similar addictive effect, fructose and ethanol share<br \/>\n     analogies in liver metabolism. Metabolites from alcohol metabolism are<br \/>\n     comparable to those resulting of fructose metabolism, which leads to<br \/>\n     identical toxic cellular response and hepatocyte damage.<\/li>\n<\/ul>\n<p><strong>Conclusions<\/strong><\/p>\n<ul>\n<li>Fructose has been linked to the rising<br \/>\n     incidence of obesity, insulin resistance, and NAFLD in the pediatric<br \/>\n     population. Its metabolism may parallel that of alcohol, with the<br \/>\n     production of similar subproducts and liver damage. <\/li>\n<li>Fructose consumption has increased 300% in the<br \/>\n     past 20 years, and it may have an addictive effect similar to other drugs.<br \/>\n     Therefore, banning added sugars from children&rsquo;s diets should be considered<br \/>\n     a public health priority.<\/li>\n<\/ul>\n<p><strong>Points to Consider<\/strong><\/p>\n<ul>\n<li>It is unclear whether the authors conducted a systematic review of<br \/>\nthe literature, as no details regarding the methods utilized are provided.<br \/>\nWithout evidence of a thorough and balanced review, any conclusions drawn from<br \/>\nthis review should done so with caution.<\/li>\n<li>Lifestyle interventions remain the first line of treatment for<br \/>\nNAFLD. These intervention are comprehensive and include changes to physical<br \/>\nactivity and sedentary behavior, as well as dietary changes that include an<br \/>\nincrease in fruit, vegetable and unrefined oils and cereals. <\/li>\n<\/ul>\n<p>The post <a rel=\"nofollow\" href=\"http:\/\/fructosefacts.org\/childhood-fructoholism-and-fructoholic-liver-disease\/\">Childhood Fructoholism and Fructoholic Liver Disease<\/a> appeared first on <a rel=\"nofollow\" href=\"http:\/\/fructosefacts.org\/\">FructoseFacts<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Download PDF Ribeiro A, Igual-Perez MJ, Santos Silva E and Sokal EM. Hepatology Communication 2019, 3:1; doi: 0.1002\/hep4.1291 Objective To conduct a review to provide evidence of the negative effect of high fructose consumption in childhood on future liver health, with many similarities to alcohol, and to propose strategies for its reduction and to support [&hellip;]<\/p>\n","protected":false},"author":7,"featured_media":848,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[188,24,6,169],"tags":[],"class_list":["post-17137","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-children","category-fructose","category-health-profesionals","category-research-summaries"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Childhood Fructoholism and Fructoholic Liver Disease - Calorie Control Council<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/caloriecontrol.org\/childhood-fructoholism-and-fructoholic-liver-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Childhood Fructoholism and Fructoholic Liver Disease - Calorie Control Council\" \/>\n<meta property=\"og:description\" content=\"Download PDF Ribeiro A, Igual-Perez MJ, Santos Silva E and Sokal EM. Hepatology Communication 2019, 3:1; doi: 0.1002\/hep4.1291 Objective To conduct a review to provide evidence of the negative effect of high fructose consumption in childhood on future liver health, with many similarities to alcohol, and to propose strategies for its reduction and to support [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/caloriecontrol.org\/childhood-fructoholism-and-fructoholic-liver-disease\/\" \/>\n<meta property=\"og:site_name\" content=\"Calorie Control Council\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CalorieControlCouncil\/\" \/>\n<meta property=\"article:published_time\" content=\"2019-05-21T16:46:51+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-11-06T05:13:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/caloriecontrol.org\/wp-content\/uploads\/health-pro.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"800\" \/>\n\t<meta property=\"og:image:height\" content=\"534\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@CalorieControlC\" \/>\n<meta name=\"twitter:site\" content=\"@CalorieControlC\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/caloriecontrol.org\/childhood-fructoholism-and-fructoholic-liver-disease\/\",\"url\":\"https:\/\/caloriecontrol.org\/childhood-fructoholism-and-fructoholic-liver-disease\/\",\"name\":\"Childhood Fructoholism and Fructoholic Liver Disease - Calorie Control Council\",\"isPartOf\":{\"@id\":\"https:\/\/caloriecontrol.org\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/caloriecontrol.org\/childhood-fructoholism-and-fructoholic-liver-disease\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/caloriecontrol.org\/childhood-fructoholism-and-fructoholic-liver-disease\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/caloriecontrol.org\/wp-content\/uploads\/health-pro.jpg\",\"datePublished\":\"2019-05-21T16:46:51+00:00\",\"dateModified\":\"2020-11-06T05:13:21+00:00\",\"author\":{\"@id\":\"\"},\"breadcrumb\":{\"@id\":\"https:\/\/caloriecontrol.org\/childhood-fructoholism-and-fructoholic-liver-disease\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/caloriecontrol.org\/childhood-fructoholism-and-fructoholic-liver-disease\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/caloriecontrol.org\/childhood-fructoholism-and-fructoholic-liver-disease\/#primaryimage\",\"url\":\"https:\/\/caloriecontrol.org\/wp-content\/uploads\/health-pro.jpg\",\"contentUrl\":\"https:\/\/caloriecontrol.org\/wp-content\/uploads\/health-pro.jpg\",\"width\":800,\"height\":534},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/caloriecontrol.org\/childhood-fructoholism-and-fructoholic-liver-disease\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/caloriecontrol.org\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Childhood Fructoholism and Fructoholic Liver Disease\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/caloriecontrol.org\/#website\",\"url\":\"https:\/\/caloriecontrol.org\/\",\"name\":\"Calorie Control Council\",\"description\":\"Healthy Eating &amp; Exercise for Life\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/caloriecontrol.org\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"\",\"url\":\"https:\/\/caloriecontrol.org\/author\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Childhood Fructoholism and Fructoholic Liver Disease - Calorie Control Council","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/caloriecontrol.org\/childhood-fructoholism-and-fructoholic-liver-disease\/","og_locale":"en_US","og_type":"article","og_title":"Childhood Fructoholism and Fructoholic Liver Disease - Calorie Control Council","og_description":"Download PDF Ribeiro A, Igual-Perez MJ, Santos Silva E and Sokal EM. 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