{"id":15844,"date":"2017-05-09T16:21:50","date_gmt":"2017-05-09T20:21:50","guid":{"rendered":"http:\/\/caloriecontrol.org\/efsa-confirms-safety-of-sucralose-rejecting-findings-of-ramazzini-institute\/"},"modified":"2017-05-10T12:40:53","modified_gmt":"2017-05-10T16:40:53","slug":"efsa-confirms-safety-of-sucralose-rejecting-findings-of-ramazzini-institute","status":"publish","type":"post","link":"https:\/\/caloriecontrol.org\/efsa-confirms-safety-of-sucralose-rejecting-findings-of-ramazzini-institute\/","title":{"rendered":"EFSA Confirms Safety of Sucralose, Rejecting Findings of Ramazzini Institute"},"content":{"rendered":"<p>In April 2017, the European Food Safety Authority\u2019s (EFSA) Scientific Panel on Food Additives and Nutrient Sources Added to Food (ANS) discussed the 2016 <a href=\"http:\/\/www.mpwhi.com\/sucralose_int_jour_occup_and_environ_healt_2016.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">publication<\/a> by Soffritti et al., from the Ramazzini Institute on the carcinogenic potential of sucralose. ANS has now published a <a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.2903\/j.efsa.2017.4784\/pdf\" target=\"_blank\" rel=\"noopener noreferrer\">statement<\/a> regarding the study and the authors\u2019 conclusions, dismissing the Ramazzini Institute\u2019s findings due to significant limitations.<\/p>\n<p>In their statement, the ANS Panel noted areas of major concern regarding the Soffritti et al. (2016) study, the technical report and additional information provided by the Ramazzini Institute for the Panel\u2019s consideration. The concerns included:<\/p>\n<ul>\n<li>a lack of a dose\u2013response relationship,<\/li>\n<li>no mode of action, and<\/li>\n<li>failure to meet all the Bradford-Hill considerations for a cause\u2013effect relationship, a study design that increases the difficulty of appropriate data interpretation particularly due to limited control database.<\/li>\n<\/ul>\n<p>Therefore, the Panel concluded that the available data did not support the conclusions of the authors (Soffritti et al., 2016) that sucralose induced haematopoietic neoplasias in male Swiss mice.<\/p>\n<p>The concerns related to this evaluation of cancer in mice fed sucralose are similar to concerns that <a href=\"http:\/\/www.efsa.europa.eu\/en\/efsajournal\/pub\/2089\" target=\"_blank\" rel=\"noopener noreferrer\">EFSA raised in 2011<\/a> when they stated, \u201cRegarding the design of the study, EFSA advised that experimental studies carried out over animals\u2019 lifetimes can lead to erroneous conclusions. Older animals for instance are more susceptible to illness and when a carcinogenicity study in mice is extended beyond the recommended 104 weeks, age-related pathological changes (such as spontaneous tumours) can appear which may confound the interpretation of any compound-related effects.\u201d<\/p>\n<p>Importantly, an extensive database of other studies conducted to assess possible carcinogenicity of sucralose does not show any reliable evidence of a cancer risk. Hundreds of publications related to sucralose have been reviewed by regulatory authorities around the world, including the Joint Food and Agricultural Organization\/World Health Organization (FAO\/WHO) Expert Committee on Food Additives (JECFA), the United States Food and Drug Administration (FDA), and the European Commission\u2019s Scientific Committee for Food (now EFSA). All of these organizations continue to agree that sucralose is safe. Additionally, sucralose has numerous benefits, including those related to oral health, diabetes and blood glucose management, and weight management. These factors are important for health and the <a href=\"http:\/\/sucralose.org\/sucralose-benefits\/\" target=\"_blank\" rel=\"noopener noreferrer\">benefits<\/a> of taste and versatility in cooking that make it a simple substitute for sugar and other caloric sweeteners.<\/p>\n<h6>Photo: Lucio Rossi for EFSA, Studio Valle Progettazioni, Art &amp; Build, Manens -Tifs, Pool Engineering, Art Ambiente Risorse e Territorio<\/h6>\n<p>The post <a href=\"http:\/\/sucralose.org\/efsa-confirms-safety-sucralose-rejecting-findings-ramazzini-institute\/\" rel=\"nofollow\">EFSA Confirms Safety of Sucralose, Rejecting Findings of Ramazzini Institute<\/a> appeared first on <a href=\"http:\/\/sucralose.org\/\" rel=\"nofollow\">Sucralose<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In April 2017, the European Food Safety Authority\u2019s (EFSA) Scientific Panel on Food Additives and Nutrient Sources Added to Food (ANS) discussed the 2016 publication by Soffritti et al., from the Ramazzini Institute on the carcinogenic potential of sucralose. ANS has now published a statement regarding the study and the authors\u2019 conclusions, dismissing the Ramazzini [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":15853,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,56,86],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>EFSA Confirms Safety of Sucralose, Rejecting Findings of Ramazzini Institute - Calorie Control Council<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/caloriecontrol.org\/efsa-confirms-safety-of-sucralose-rejecting-findings-of-ramazzini-institute\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"EFSA Confirms Safety of Sucralose, Rejecting Findings of Ramazzini Institute - Calorie Control Council\" \/>\n<meta property=\"og:description\" content=\"In April 2017, the European Food Safety Authority\u2019s (EFSA) Scientific Panel on Food Additives and Nutrient Sources Added to Food (ANS) discussed the 2016 publication by Soffritti et al., from the Ramazzini Institute on the carcinogenic potential of sucralose. 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