{"id":17135,"date":"2019-05-21T12:44:43","date_gmt":"2019-05-21T16:44:43","guid":{"rendered":"https:\/\/caloriecontrol.org\/the-effect-of-a-new-mixture-of-sugar-and-sugar-alcohols-compared-to-sucrose-and-glucose-on-blood-glucose-increase-and-the-possible-adverse-reactions-a-phase-i-double-blind-three-way-randomized-cross\/"},"modified":"2019-07-09T19:03:58","modified_gmt":"2019-07-09T23:03:58","slug":"the-effect-of-a-new-mixture-of-sugar-and-sugar-alcohols-compared-to-sucrose-and-glucose-on-blood-glucose-increase-and-the-possible-adverse-reactions-a-phase-i-double-blind-three-way-randomized-cross","status":"publish","type":"post","link":"https:\/\/caloriecontrol.org\/the-effect-of-a-new-mixture-of-sugar-and-sugar-alcohols-compared-to-sucrose-and-glucose-on-blood-glucose-increase-and-the-possible-adverse-reactions-a-phase-i-double-blind-three-way-randomized-cross\/","title":{"rendered":"The effect of a new mixture of sugar and sugar-alcohols compared to sucrose and glucose on blood glucose increase and the possible adverse reactions: A phase I double-blind, three-way randomized cross-over clinical trial"},"content":{"rendered":"<p><em>Endocrinol Diabetes Nutr.<\/em> 2019. https:\/\/doi.org\/10.1016\/j.endinu.2018.12.008<\/p>\n<p>Mohsenpour MA, Kaseb F, Nazemian R, et al.<\/p>\n<p><a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S253001641930031X?via%3Dihub\">Download Research Study PDF<\/a><\/p>\n<p><strong>Objective<\/strong><\/p>\n<ul>\n<li>To<br \/>\nexamine the effect of a new mixture of sugars and sugar alcohol on the<br \/>\npostprandial blood glucose levels and its possible gastrointestinal (GI)<br \/>\nadverse reactions in human adults.<\/li>\n<\/ul>\n<p><strong>Background<\/strong><\/p>\n<ul>\n<li>Various compounds such as sugars, sugar<br \/>\nalcohols and non-sugar compounds (stevia, xylitol, and aspartame) have<br \/>\nbeen introduced to induce the sweet taste in food industry.<\/li>\n<li>Lacritose, a new sweetener, was recently introduced<br \/>\nby mixing the following four sugars: lactose, fructose, sucrose, and<br \/>\nerythritol.<\/li>\n<li>Although previous studies have shown sugars can<br \/>\ninteract each other during absorption in the intestine and slowdown or<br \/>\nincrease each other\u2019s absorption, further research is needed regarding the<br \/>\nglycemic response and possible gastrointestinal adverse reactions associated<br \/>\nwith Lacritose.<\/li>\n<\/ul>\n<p><strong>Methods<\/strong><\/p>\n<ul>\n<li>Forty participants, including 20 diabetic<br \/>\npatients and 20 healthy individuals, ages 20-60 (mean age = 40) were<br \/>\nenrolled between February and October of2016.<\/li>\n<li>A double-blind, three way randomized cross-over<br \/>\nclinical trial was conducted in which each participant served as his\/her<br \/>\nown control. After fasting overnight for at least 10 hours, participants<br \/>\nwere randomly given 300ml servings of three beverages containing 50g<br \/>\nglucose, sucrose and lacritose. Blood samples were collected before and<br \/>\nafterwards every 30 minutes for up to 2 hours.&nbsp;<\/li>\n<li>Demographic data was collected and<br \/>\nanthropometric assessments were conducted on each intervention day.&nbsp; A gastrointestinal reaction questionnaire,<br \/>\nwhich assessed pain in the stomach and abdomen, heartburn, reflux,<br \/>\nappetite, etc., was completed for each participant one day after the<br \/>\nintervention day by a trained nutritionist on the phone.<\/li>\n<\/ul>\n<p><strong>Findings<\/strong><\/p>\n<ul>\n<li>Mean blood glucose was significantly lower<br \/>\nduring consumptions of lacritose compared to sucrose and glucose (mean\u00b1<br \/>\nstandard error (SE) for lacritose: 114.9 \u00b1 2.5, glucose:154.8 \u00b1 5.0,<br \/>\nsucrose: 134.3 \u00b1 4.0, P-value &lt;0.001).&nbsp;<br \/>\nAlso the increasing of blood glucose at different times was<br \/>\nsignificantly different between the three drinks.<\/li>\n<li>In both participants with diabetes mellitus and<br \/>\nhealthy subjects, blood glucose was significantly lower after ingesting<br \/>\nlacritose when compared to other beverages, after adjustment for BMI,<br \/>\ngender, age and rolling method (P-value &lt;0.05).<\/li>\n<li>The number of participants reporting abdominal<br \/>\npain, epigastric pain and also nausea after ingestion of the test<br \/>\nbeverages were higher when they ingested lacritose.&nbsp; However the difference between beverages<br \/>\nwere not statistically significant for abdominal pain (P-value = 0.165),<br \/>\nepigastric pain (P-value = 0.097) and nausea (P-value = 0.717).<\/li>\n<\/ul>\n<p><strong>Conclusions<\/strong><\/p>\n<ul>\n<li>Blood glucose levels were significantly lower<br \/>\nafter ingestion of one 50 g dose of lacritose, as compared to identical servings<br \/>\nof glucose and sucrose.<\/li>\n<li>Although lacritose contains lactose, the<br \/>\ngastrointestinal adverse reactions after its ingestion was not<br \/>\nsignificantly different compared to glucose and sucrose.<\/li>\n<li>Further studies with more study participants<br \/>\nexamining the long-term effects of lacritose on appetite, body weight and<br \/>\nother metabolic markers of long-term glucose control are recommended.<\/li>\n<\/ul>\n<p><strong>Points to Consider<\/strong><\/p>\n<ul>\n<li>The present study included a sample of only 40<br \/>\nparticipants and did not assess the effect of lacritose on appetite, insulin<br \/>\nresponse and long-term outcomes.<\/li>\n<li>The long-term effect of lacritose on overall<br \/>\nhealth are unknown and given its relatively high amount of lactose and<br \/>\nerythritol, they may be adverse reactions associated with long-term use. &nbsp;<\/li>\n<\/ul>\n<p>The post <a rel=\"nofollow\" href=\"http:\/\/fructosefacts.org\/the-effect-of-a-new-mixture-of-sugar-and-sugar-alcohols-compared-to-sucrose-and-glucose-on-blood-glucose-increase-and-the-possible-adverse-reactions-a-phase-i-double-blind-three-way-randomized-cross\/\">The effect of a new mixture of sugar and sugar-alcohols compared to sucrose and glucose on blood glucose increase and the possible adverse reactions: A phase I double-blind, three-way randomized cross-over clinical trial<\/a> appeared first on <a rel=\"nofollow\" href=\"http:\/\/fructosefacts.org\/\">FructoseFacts<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Endocrinol Diabetes Nutr. 2019. https:\/\/doi.org\/10.1016\/j.endinu.2018.12.008 Mohsenpour MA, Kaseb F, Nazemian R, et al. Download Research Study PDF Objective To examine the effect of a new mixture of sugars and sugar alcohol on the postprandial blood glucose levels and its possible gastrointestinal (GI) adverse reactions in human adults. Background Various compounds such as sugars, sugar alcohols [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":848,"comment_status":"close","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[24,6,169],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The effect of a new mixture of sugar and sugar-alcohols compared to sucrose and glucose on blood glucose increase and the possible adverse reactions: A phase I double-blind, three-way randomized cross-over clinical trial - Calorie Control Council<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/caloriecontrol.org\/the-effect-of-a-new-mixture-of-sugar-and-sugar-alcohols-compared-to-sucrose-and-glucose-on-blood-glucose-increase-and-the-possible-adverse-reactions-a-phase-i-double-blind-three-way-randomized-cross\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The effect of a new mixture of sugar and sugar-alcohols compared to sucrose and glucose on blood glucose increase and the possible adverse reactions: A phase I double-blind, three-way randomized cross-over clinical trial - Calorie Control Council\" \/>\n<meta property=\"og:description\" content=\"Endocrinol Diabetes Nutr. 2019. https:\/\/doi.org\/10.1016\/j.endinu.2018.12.008 Mohsenpour MA, Kaseb F, Nazemian R, et al. 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